Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 5213736..5214301 Replicon chromosome
Accession NZ_CP098609
Organism Streptomyces filamentosus strain L30

Toxin (Protein)


Gene name doc Uniprot ID V6UA48
Locus tag K7395_RS23090 Protein ID WP_010070918.1
Coordinates 5213933..5214301 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V6UAG4
Locus tag K7395_RS23085 Protein ID WP_006124909.1
Coordinates 5213736..5213933 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7395_RS23065 (K7395_23065) 5210286..5210966 + 681 WP_006124913.1 hypothetical protein -
K7395_RS23070 (K7395_23070) 5211034..5211810 + 777 WP_006124912.1 hypothetical protein -
K7395_RS23080 (K7395_23080) 5212195..5213700 + 1506 WP_252096546.1 MFS transporter -
K7395_RS23085 (K7395_23085) 5213736..5213933 + 198 WP_006124909.1 hypothetical protein Antitoxin
K7395_RS23090 (K7395_23090) 5213933..5214301 + 369 WP_010070918.1 Fic family protein Toxin
K7395_RS23095 (K7395_23095) 5214470..5216254 + 1785 WP_006124907.1 DEAD/DEAH box helicase -
K7395_RS23100 (K7395_23100) 5216780..5217424 + 645 WP_006124906.1 helix-turn-helix domain-containing protein -
K7395_RS23105 (K7395_23105) 5217534..5218322 + 789 WP_006124905.1 S16 family serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(12-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13709.69 Da        Isoelectric Point: 4.8727

>T247750 WP_010070918.1 NZ_CP098609:5213933-5214301 [Streptomyces filamentosus]
MQYLTLPELLKLAERLGAAEVRDYGLLESALTRPQASVFGQDAYPDVWQKAAALMESLARNHGLIDGNKRIAWYATWVFL
HLNGHPLDPDFDVDEAERFVLAACQGALDMPKIAEQLPRFAR

Download         Length: 369 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7293.14 Da        Isoelectric Point: 5.5840

>AT247750 WP_006124909.1 NZ_CP098609:5213736-5213933 [Streptomyces filamentosus]
MAGLNLRFTEEELNSLRARAEAEGRSMQAFAHDAVITAINEHSRLFNEAADHVLKASEELNRRLA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6UA48

Antitoxin

Source ID Structure
AlphaFold DB V6UAG4

References