Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 3419732..3420292 Replicon chromosome
Accession NZ_CP098609
Organism Streptomyces filamentosus strain L30

Toxin (Protein)


Gene name relE Uniprot ID V6UJL0
Locus tag K7395_RS14710 Protein ID WP_006126599.1
Coordinates 3420014..3420292 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K7395_RS14705 Protein ID WP_202473555.1
Coordinates 3419732..3420010 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7395_RS14685 (K7395_14685) 3415079..3416272 + 1194 WP_010071676.1 ABC transporter permease -
K7395_RS14690 (K7395_14690) 3416322..3417419 - 1098 WP_006126603.1 type II CAAX endopeptidase family protein -
K7395_RS14695 (K7395_14695) 3417663..3418448 + 786 WP_006126602.1 SAM-dependent methyltransferase -
K7395_RS14700 (K7395_14700) 3418421..3419536 - 1116 WP_006126601.1 hypothetical protein -
K7395_RS14705 (K7395_14705) 3419732..3420010 + 279 WP_202473555.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K7395_RS14710 (K7395_14710) 3420014..3420292 + 279 WP_006126599.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7395_RS14715 (K7395_14715) 3420338..3420952 - 615 WP_006126598.1 TetR-like C-terminal domain-containing protein -
K7395_RS14720 (K7395_14720) 3421021..3422367 + 1347 WP_006126597.1 alpha/beta hydrolase -
K7395_RS14725 (K7395_14725) 3422439..3422771 + 333 WP_010071670.1 type II toxin-antitoxin system PemK/MazF family toxin -
K7395_RS14730 (K7395_14730) 3422799..3423233 - 435 WP_032771498.1 hypothetical protein -
K7395_RS14735 (K7395_14735) 3423351..3424121 + 771 WP_032771497.1 helix-turn-helix transcriptional regulator -
K7395_RS14740 (K7395_14740) 3424118..3424321 + 204 WP_006126593.1 DUF397 domain-containing protein -
K7395_RS14745 (K7395_14745) 3424371..3424778 + 408 WP_234013144.1 DUF6336 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10591.24 Da        Isoelectric Point: 10.4171

>T247748 WP_006126599.1 NZ_CP098609:3420014-3420292 [Streptomyces filamentosus]
MGHVTRFTAHAQRDLLKIPLPEARRILGRLADLQKALDAGELSAFDVKPLQGHDARWRLRVGDYRAVYTVEDGQLIVWVL
AVAHRREIYRSF

Download         Length: 279 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10403.58 Da        Isoelectric Point: 4.4385

>AT247748 WP_202473555.1 NZ_CP098609:3419732-3420010 [Streptomyces filamentosus]
MSEPVTESMAEVRKHLADVIDRARRDETPTIITRRGKSEAVLVDIDEYRRLREVAEQYEDGWLNRLADKAEAEGTDGSVS
LEEMAALLRSAN

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6UJL0

Antitoxin

Source ID Structure

References