Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 651379..652034 Replicon chromosome
Accession NZ_CP098548
Organism Neisseria gonorrhoeae strain 9343

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NDQ69_RS03475 Protein ID WP_229931500.1
Coordinates 651615..652034 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDQ69_RS03470 Protein ID WP_003688410.1
Coordinates 651379..651615 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ69_RS03440 (NDQ69_03405) 646514..646801 + 288 WP_003688407.1 hypothetical protein -
NDQ69_RS03445 (NDQ69_03410) 646873..648039 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDQ69_RS03450 (NDQ69_03415) 648050..648940 + 891 WP_229931474.1 succinate--CoA ligase subunit alpha -
NDQ69_RS03455 (NDQ69_03420) 649323..649709 - 387 Protein_674 transposase -
NDQ69_RS03460 (NDQ69_11765) 649948..650349 + 402 WP_020996834.1 helix-turn-helix domain-containing protein -
NDQ69_RS03465 (NDQ69_03430) 650354..650932 + 579 WP_003697246.1 IS3 family transposase -
NDQ69_RS03470 (NDQ69_03435) 651379..651615 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDQ69_RS03475 (NDQ69_03440) 651615..652034 + 420 WP_229931500.1 type II toxin-antitoxin system toxin FitB Toxin
NDQ69_RS03480 (NDQ69_03445) 652183..653637 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDQ69_RS03485 (NDQ69_03450) 653634..654335 - 702 WP_003688414.1 lactate utilization protein C -
NDQ69_RS03490 (NDQ69_03455) 654332..655111 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDQ69_RS03495 (NDQ69_03460) 655259..656800 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15336.67 Da        Isoelectric Point: 5.5742

>T247741 WP_229931500.1 NZ_CP098548:651615-652034 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGWILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247741 WP_003688410.1 NZ_CP098548:651379-651615 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References