247740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 101..4123 Replicon plasmid pJD1
Accession NZ_CP098547
Organism Neisseria gonorrhoeae strain 9126

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NDQ67_RS11730 Protein ID WP_003690225.1
Coordinates 101..379 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NDQ67_RS11725 Protein ID WP_003690223.1
Coordinates 4123..101 (+) Length -1340.3333333333 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ67_RS11730 (NDQ67_11730) 101..379 + 279 WP_003690225.1 endoribonuclease VapD Toxin
NDQ67_RS11735 (NDQ67_11735) 357..611 - 255 WP_003690227.1 Cryptic plasmid protein A -
NDQ67_RS11740 (NDQ67_11690) 658..1299 - 642 WP_003690229.1 MbeB family mobilization protein -
NDQ67_RS11745 (NDQ67_11695) 1383..2012 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
NDQ67_RS11750 (NDQ67_11700) 1997..2377 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
NDQ67_RS11755 (NDQ67_11705) 2456..2680 + 225 WP_025455920.1 hypothetical protein -
NDQ67_RS11760 (NDQ67_11710) 2763..3632 + 870 WP_003690219.1 replication initiation protein -
NDQ67_RS11765 (NDQ67_11715) 3636..3878 + 243 WP_003690220.1 HTH domain-containing protein -
NDQ67_RS11770 (NDQ67_11720) 3875..4120 + 246 WP_003690221.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247740 WP_003690225.1 NZ_CP098547:101-379 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: -1340.3333333333 a.a.        Molecular weight: Da        Isoelectric Point:

>AT247740 WP_003690223.1 NZ_CP098547:4123-101 [Neisseria gonorrhoeae]

Download         Length: -4021 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References