Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1853055..1853683 Replicon chromosome
Accession NC_014209
Organism Thermoanaerobacter mathranii subsp. mathranii str. A3

Toxin (Protein)


Gene name mazF Uniprot ID B0KD57
Locus tag TMATH_RS09145 Protein ID WP_003867472.1
Coordinates 1853055..1853405 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B0KD56
Locus tag TMATH_RS09150 Protein ID WP_003867471.1
Coordinates 1853408..1853683 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TMATH_RS09125 1848548..1849282 - 735 WP_013150743.1 WecB/TagA/CpsF family glycosyltransferase -
TMATH_RS09130 1849285..1850376 - 1092 WP_013150744.1 polysaccharide pyruvyl transferase CsaB -
TMATH_RS09135 1850378..1852390 - 2013 WP_013150745.1 hypothetical protein -
TMATH_RS09140 1852505..1852957 - 453 WP_013150746.1 hypothetical protein -
TMATH_RS09145 1853055..1853405 - 351 WP_003867472.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
TMATH_RS09150 1853408..1853683 - 276 WP_003867471.1 ribbon-helix-helix protein, CopG family Antitoxin
TMATH_RS09155 1853781..1854938 - 1158 WP_013150747.1 alanine racemase -
TMATH_RS09160 1854958..1855965 - 1008 WP_013150748.1 outer membrane lipoprotein carrier protein LolA -
TMATH_RS09165 1855977..1857509 - 1533 WP_013150749.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
TMATH_RS09170 1857472..1857888 - 417 WP_012995812.1 holo-ACP synthase -
TMATH_RS09175 1857983..1858348 - 366 WP_013150750.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12933.02 Da        Isoelectric Point: 6.4714

>T24774 WP_003867472.1 NC_014209:c1853405-1853055 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
MVIKRGDIFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLNKDSVVLLEQI
RTIDKKRLREKIGHFDQEMMEKVNEALQISLGLIDF

Download         Length: 351 bp

>T24774 NC_014209:c1853405-1853055 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
ATGGTGATAAAGAGGGGAGATATTTTTTATGCCGATTTAAGCCCTGTAATAGGCTCTGAACAGGGCGGAATTCGGCCTGT
ACTTATAATTCAAAATGATATTGGCAATAAATATAGTCCAACAGTAATAGTAGCGGCAATTACCTCTCAGATCAACAAAG
CCAAATTGCCCACTCATGTTGAAATAAATGGGGCAGAATATGGACTTAACAAAGATTCTGTAGTATTGTTAGAACAAATT
AGGACTATTGACAAAAAACGTTTAAGAGAAAAAATTGGCCATTTTGACCAGGAAATGATGGAGAAAGTCAATGAAGCTTT
GCAAATAAGTTTGGGGTTAATTGACTTTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10533.33 Da        Isoelectric Point: 6.3661

>AT24774 WP_003867471.1 NC_014209:c1853683-1853408 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
VGETKRILVSLPQSLLEEVDVLAAMENRNRSEFIREAMKLYIREKKKIQIRESMKKGYLEMAAINSELAEMGLTAENECF
TGYEMKLKKCD

Download         Length: 276 bp

>AT24774 NC_014209:c1853683-1853408 [Thermoanaerobacter mathranii subsp. mathranii str. A3]
GTGGGCGAAACAAAGCGAATACTTGTGAGCTTGCCGCAGAGTTTATTAGAAGAGGTTGATGTTCTTGCCGCTATGGAAAA
CAGGAACCGCAGTGAATTTATAAGAGAAGCGATGAAATTATATATACGGGAGAAGAAAAAAATTCAAATACGAGAGAGCA
TGAAAAAGGGATATCTTGAGATGGCAGCGATTAACAGTGAACTTGCGGAAATGGGCCTAACCGCAGAAAACGAATGCTTT
ACAGGATACGAAATGAAATTGAAAAAGTGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B3BRL3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4W2H3

References