247737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 36..4004 Replicon plasmid pJD1
Accession NZ_CP098545
Organism Neisseria gonorrhoeae strain 10296

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NDQ64_RS11700 Protein ID WP_003690225.1
Coordinates 36..314 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NDQ64_RS11695 Protein ID WP_003690223.1
Coordinates 4004..36 (+) Length -1322.3333333333 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ64_RS11700 (NDQ64_11590) 36..314 + 279 WP_003690225.1 endoribonuclease VapD Toxin
NDQ64_RS11705 (NDQ64_11595) 292..546 - 255 WP_003690227.1 Cryptic plasmid protein A -
NDQ64_RS11710 (NDQ64_11600) 593..1180 - 588 WP_003692168.1 MbeB family mobilization protein -
NDQ64_RS11715 (NDQ64_11605) 1264..1893 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
NDQ64_RS11720 (NDQ64_11610) 1878..2258 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
NDQ64_RS11725 (NDQ64_11615) 2644..3513 + 870 WP_003690219.1 replication initiation protein -
NDQ64_RS11730 (NDQ64_11620) 3517..3759 + 243 WP_003690220.1 HTH domain-containing protein -
NDQ64_RS11735 (NDQ64_11625) 3756..4001 + 246 WP_003690221.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4153 4153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247737 WP_003690225.1 NZ_CP098545:36-314 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: -1322.3333333333 a.a.        Molecular weight: Da        Isoelectric Point:

>AT247737 WP_003690223.1 NZ_CP098545:4004-36 [Neisseria gonorrhoeae]

Download         Length: -3967 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References