Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1016700..1017355 Replicon chromosome
Accession NZ_CP098544
Organism Neisseria gonorrhoeae strain 10296

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDQ64_RS05270 Protein ID WP_003691083.1
Coordinates 1016700..1017119 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDQ64_RS05275 Protein ID WP_003688410.1
Coordinates 1017119..1017355 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ64_RS05250 (NDQ64_05190) 1011934..1013475 - 1542 WP_003697015.1 MDR family MFS transporter -
NDQ64_RS05255 (NDQ64_05195) 1013623..1014402 + 780 WP_003688416.1 (Fe-S)-binding protein -
NDQ64_RS05260 (NDQ64_05200) 1014399..1015100 + 702 WP_003688414.1 lactate utilization protein C -
NDQ64_RS05265 (NDQ64_05205) 1015097..1016551 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDQ64_RS05270 (NDQ64_05210) 1016700..1017119 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDQ64_RS05275 (NDQ64_05215) 1017119..1017355 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDQ64_RS05280 (NDQ64_05220) 1017802..1018380 - 579 WP_003688041.1 IS3 family transposase -
NDQ64_RS05285 (NDQ64_05225) 1018385..1018786 - 402 WP_020997339.1 helix-turn-helix domain-containing protein -
NDQ64_RS05290 (NDQ64_05230) 1019025..1019411 + 387 Protein_1035 transposase -
NDQ64_RS05295 (NDQ64_05235) 1019794..1020684 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NDQ64_RS05300 (NDQ64_05240) 1020695..1021861 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDQ64_RS05305 (NDQ64_05245) 1021933..1022220 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1019004..1019477 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247736 WP_003691083.1 NZ_CP098544:c1017119-1016700 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247736 WP_003688410.1 NZ_CP098544:c1017355-1017119 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References