Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1149..1612 Replicon plasmid pJD1
Accession NZ_CP098543
Organism Neisseria gonorrhoeae strain 10704

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NDQ68_RS11725 Protein ID WP_003690225.1
Coordinates 1334..1612 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NDQ68_RS11720 Protein ID WP_003690223.1
Coordinates 1149..1334 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ68_RS11710 (NDQ68_11635) 662..904 + 243 WP_003690220.1 HTH domain-containing protein -
NDQ68_RS11715 (NDQ68_11640) 901..1146 + 246 WP_003690221.1 hypothetical protein -
NDQ68_RS11720 (NDQ68_11645) 1149..1334 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
NDQ68_RS11725 (NDQ68_11650) 1334..1612 + 279 WP_003690225.1 endoribonuclease VapD Toxin
NDQ68_RS11730 (NDQ68_11655) 1590..1844 - 255 WP_003690227.1 Cryptic plasmid protein A -
NDQ68_RS11735 (NDQ68_11660) 1891..2532 - 642 WP_003690229.1 MbeB family mobilization protein -
NDQ68_RS11740 (NDQ68_11615) 2616..3245 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
NDQ68_RS11745 (NDQ68_11620) 3230..3610 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
NDQ68_RS11750 (NDQ68_11625) 3689..3913 + 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247734 WP_003690225.1 NZ_CP098543:1334-1612 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT247734 WP_003690223.1 NZ_CP098543:1149-1334 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References