Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 652361..653016 Replicon chromosome
Accession NZ_CP098542
Organism Neisseria gonorrhoeae strain 10704

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDQ68_RS03480 Protein ID WP_003691083.1
Coordinates 652597..653016 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDQ68_RS03475 Protein ID WP_003688410.1
Coordinates 652361..652597 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ68_RS03445 (NDQ68_03410) 647496..647783 + 288 WP_003688407.1 hypothetical protein -
NDQ68_RS03450 (NDQ68_03415) 647855..649021 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDQ68_RS03455 (NDQ68_03420) 649032..649922 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
NDQ68_RS03460 (NDQ68_03425) 650305..650691 - 387 Protein_675 IS110 family transposase -
NDQ68_RS03465 (NDQ68_03430) 651041..651331 + 291 WP_047917062.1 helix-turn-helix domain-containing protein -
NDQ68_RS03470 (NDQ68_03435) 651336..651914 + 579 WP_003697246.1 IS3 family transposase -
NDQ68_RS03475 (NDQ68_03440) 652361..652597 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDQ68_RS03480 (NDQ68_03445) 652597..653016 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDQ68_RS03485 (NDQ68_03450) 653165..654619 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDQ68_RS03490 (NDQ68_03455) 654616..655317 - 702 WP_003688414.1 lactate utilization protein C -
NDQ68_RS03495 (NDQ68_03460) 655314..656093 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDQ68_RS03500 (NDQ68_03465) 656241..657782 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247732 WP_003691083.1 NZ_CP098542:652597-653016 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247732 WP_003688410.1 NZ_CP098542:652361-652597 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References