Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 650929..651584 Replicon chromosome
Accession NZ_CP098538
Organism Neisseria gonorrhoeae strain ATCC 49226

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDQ65_RS03490 Protein ID WP_003691083.1
Coordinates 651165..651584 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDQ65_RS03485 Protein ID WP_003688410.1
Coordinates 650929..651165 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ65_RS03455 (NDQ65_03450) 646062..646349 + 288 WP_025455945.1 hypothetical protein -
NDQ65_RS03460 (NDQ65_03455) 646421..647587 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
NDQ65_RS03465 (NDQ65_03460) 647598..648488 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
NDQ65_RS03470 (NDQ65_03465) 648871..649257 - 387 Protein_677 transposase -
NDQ65_RS03475 (NDQ65_03470) 649496..649897 + 402 WP_020997337.1 helix-turn-helix domain-containing protein -
NDQ65_RS03480 (NDQ65_03475) 649902..650723 + 822 WP_010358440.1 IS3 family transposase -
NDQ65_RS03485 (NDQ65_03480) 650929..651165 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDQ65_RS03490 (NDQ65_03485) 651165..651584 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDQ65_RS03495 (NDQ65_03490) 651733..653187 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDQ65_RS03500 (NDQ65_03495) 653184..653885 - 702 WP_003688414.1 lactate utilization protein C -
NDQ65_RS03505 (NDQ65_03500) 653882..654661 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDQ65_RS03510 (NDQ65_03505) 654809..656350 + 1542 WP_003701286.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 648805..649278 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247730 WP_003691083.1 NZ_CP098538:651165-651584 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247730 WP_003688410.1 NZ_CP098538:650929-651165 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References