Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1411..1874 Replicon plasmid pJD1
Accession NZ_CP098537
Organism Neisseria gonorrhoeae strain 10771

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NDQ63_RS11650 Protein ID WP_003690225.1
Coordinates 1596..1874 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NDQ63_RS11645 Protein ID WP_003690223.1
Coordinates 1411..1596 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ63_RS11630 (NDQ63_11545) 51..920 + 870 WP_003690219.1 replication initiation protein -
NDQ63_RS11635 (NDQ63_11550) 924..1166 + 243 WP_003690220.1 HTH domain-containing protein -
NDQ63_RS11640 (NDQ63_11555) 1163..1408 + 246 WP_003690221.1 hypothetical protein -
NDQ63_RS11645 (NDQ63_11560) 1411..1596 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
NDQ63_RS11650 (NDQ63_11565) 1596..1874 + 279 WP_003690225.1 endoribonuclease VapD Toxin
NDQ63_RS11655 (NDQ63_11570) 1852..2106 - 255 WP_003690227.1 Cryptic plasmid protein A -
NDQ63_RS11660 (NDQ63_11575) 2153..2794 - 642 WP_003690229.1 MbeB family mobilization protein -
NDQ63_RS11665 (NDQ63_11580) 2878..3507 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
NDQ63_RS11670 (NDQ63_11585) 3492..3872 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
NDQ63_RS11675 (NDQ63_11590) 3951..4175 + 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247729 WP_003690225.1 NZ_CP098537:1596-1874 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT247729 WP_003690223.1 NZ_CP098537:1411-1596 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References