Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 723171..723826 Replicon chromosome
Accession NZ_CP098534
Organism Neisseria gonorrhoeae strain 10525

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDQ70_RS03875 Protein ID WP_003691083.1
Coordinates 723407..723826 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDQ70_RS03870 Protein ID WP_003688410.1
Coordinates 723171..723407 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ70_RS03840 (NDQ70_05715) 718305..718592 + 288 WP_003688407.1 hypothetical protein -
NDQ70_RS03845 (NDQ70_05710) 718664..719830 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
NDQ70_RS03850 (NDQ70_05705) 719841..720731 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NDQ70_RS03855 (NDQ70_05700) 721114..721500 - 387 Protein_748 transposase -
NDQ70_RS03860 (NDQ70_05695) 721739..722140 + 402 WP_020997339.1 helix-turn-helix domain-containing protein -
NDQ70_RS03865 (NDQ70_05690) 722145..722723 + 579 WP_003688041.1 IS3 family transposase -
NDQ70_RS03870 (NDQ70_05685) 723171..723407 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDQ70_RS03875 (NDQ70_05680) 723407..723826 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDQ70_RS03880 (NDQ70_05675) 723975..725429 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDQ70_RS03885 (NDQ70_05670) 725426..726127 - 702 WP_003688414.1 lactate utilization protein C -
NDQ70_RS03890 (NDQ70_05665) 726124..726903 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDQ70_RS03895 (NDQ70_05660) 727051..728592 + 1542 WP_003697015.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247725 WP_003691083.1 NZ_CP098534:723407-723826 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247725 WP_003688410.1 NZ_CP098534:723171-723407 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References