Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 724016..724671 Replicon chromosome
Accession NZ_CP098532
Organism Neisseria gonorrhoeae strain 10537

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDQ66_RS03895 Protein ID WP_003691083.1
Coordinates 724252..724671 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDQ66_RS03890 Protein ID WP_003688410.1
Coordinates 724016..724252 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDQ66_RS03860 (NDQ66_03840) 719150..719437 + 288 WP_003688407.1 hypothetical protein -
NDQ66_RS03865 (NDQ66_03845) 719509..720675 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
NDQ66_RS03870 (NDQ66_03850) 720686..721576 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NDQ66_RS03875 (NDQ66_03855) 721959..722345 - 387 Protein_752 transposase -
NDQ66_RS03880 (NDQ66_03860) 722584..722985 + 402 WP_020997339.1 helix-turn-helix domain-containing protein -
NDQ66_RS03885 (NDQ66_03865) 722990..723568 + 579 WP_003688041.1 IS3 family transposase -
NDQ66_RS03890 (NDQ66_03870) 724016..724252 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDQ66_RS03895 (NDQ66_03875) 724252..724671 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDQ66_RS03900 (NDQ66_03880) 724820..726274 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDQ66_RS03905 (NDQ66_03885) 726271..726972 - 702 WP_003688414.1 lactate utilization protein C -
NDQ66_RS03910 (NDQ66_03890) 726969..727748 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDQ66_RS03915 (NDQ66_03895) 727896..729437 + 1542 WP_003697015.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247723 WP_003691083.1 NZ_CP098532:724252-724671 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247723 WP_003688410.1 NZ_CP098532:724016-724252 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References