Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3312595..3313273 Replicon chromosome
Accession NZ_CP098521
Organism Acinetobacter baumannii strain Cl107

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NDN18_RS15920 Protein ID WP_000009390.1
Coordinates 3312595..3312774 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A009Q2Y3
Locus tag NDN18_RS15925 Protein ID WP_032058837.1
Coordinates 3312860..3313273 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDN18_RS15900 (NDN18_15895) 3308401..3309261 - 861 WP_196085344.1 GPO family capsid scaffolding protein -
NDN18_RS15905 (NDN18_15900) 3309440..3311218 + 1779 WP_196085343.1 terminase family protein -
NDN18_RS15910 (NDN18_15905) 3311215..3312261 + 1047 WP_254231395.1 phage portal protein -
NDN18_RS15915 (NDN18_15910) 3312272..3312487 + 216 WP_227552920.1 hypothetical protein -
NDN18_RS15920 (NDN18_15915) 3312595..3312774 + 180 WP_000009390.1 type II toxin-antitoxin system HicA family toxin Toxin
NDN18_RS15925 (NDN18_15920) 3312860..3313273 + 414 WP_032058837.1 antitoxin Antitoxin
NDN18_RS15930 (NDN18_15925) 3313533..3314051 - 519 WP_031945607.1 hypothetical protein -
NDN18_RS15955 (NDN18_15950) 3315244..3316308 - 1065 WP_001278262.1 quinolinate synthase NadA -
NDN18_RS15960 (NDN18_15955) 3316455..3317675 - 1221 WP_000268125.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3270384..3313273 42889


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(16-78)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6799.11 Da        Isoelectric Point: 11.1422

>T247721 WP_000009390.1 NZ_CP098521:3312595-3312774 [Acinetobacter baumannii]
MSFNEFKRWLIAQGVIFVRKGKGSHMIIEFNGKKTVFPNHGKKEIPEGTRLKIKKDLGL

Download         Length: 180 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15334.70 Da        Isoelectric Point: 6.2451

>AT247721 WP_032058837.1 NZ_CP098521:3312860-3313273 [Acinetobacter baumannii]
MKCYVSIHREGEAFIVSSSELPELNSVGYTLEEALSEALDGIETVFEIYMDERKAIPLPSKGKKGEYAVHLPVRVAAKVR
LYNEMISQNVTKAELARRLGWLQKQADRLLSLKHSTKLESIESAFQALGKDLDIVIA

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A009Q2Y3

References