Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 457782..458435 Replicon chromosome
Accession NZ_CP098521
Organism Acinetobacter baumannii strain Cl107

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9G864
Locus tag NDN18_RS02265 Protein ID WP_000607075.1
Coordinates 458046..458435 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag NDN18_RS02260 Protein ID WP_001288210.1
Coordinates 457782..458039 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDN18_RS02240 (NDN18_02240) 453298..454305 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
NDN18_RS02245 (NDN18_02245) 454324..454701 + 378 WP_001216380.1 50S ribosomal protein L17 -
NDN18_RS02250 (NDN18_02250) 454883..456373 + 1491 WP_000415123.1 NAD(P)/FAD-dependent oxidoreductase -
NDN18_RS02255 (NDN18_02255) 456422..457594 - 1173 WP_001190556.1 acyl-CoA dehydrogenase family protein -
NDN18_RS02260 (NDN18_02260) 457782..458039 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
NDN18_RS02265 (NDN18_02265) 458046..458435 + 390 WP_000607075.1 membrane protein Toxin
NDN18_RS02270 (NDN18_02270) 459205..460290 + 1086 WP_000049105.1 hypothetical protein -
NDN18_RS02275 (NDN18_02275) 460368..460934 + 567 WP_000651539.1 rhombosortase -
NDN18_RS02280 (NDN18_02280) 461122..463317 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.94 Da        Isoelectric Point: 10.3890

>T247720 WP_000607075.1 NZ_CP098521:458046-458435 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Download         Length: 390 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT247720 WP_001288210.1 NZ_CP098521:457782-458039 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9G864

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References