Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 236017..236653 Replicon chromosome
Accession NC_014206
Organism Geobacillus sp. C56-T3

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GC56T3_RS01265 Protein ID WP_003253417.1
Coordinates 236303..236653 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0D8C733
Locus tag GC56T3_RS01260 Protein ID WP_013144044.1
Coordinates 236017..236298 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GC56T3_RS01240 232274..232891 - 618 WP_011229737.1 rhomboid family intramembrane serine protease -
GC56T3_RS01245 233005..233394 + 390 WP_011229738.1 holo-ACP synthase -
GC56T3_RS01250 233474..234487 + 1014 WP_013144042.1 outer membrane lipoprotein carrier protein LolA -
GC56T3_RS01255 234736..235890 + 1155 WP_013144043.1 alanine racemase -
GC56T3_RS01260 236017..236298 + 282 WP_013144044.1 hypothetical protein Antitoxin
GC56T3_RS01265 236303..236653 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GC56T3_RS01270 236919..239084 + 2166 WP_013144045.1 RNA-binding transcriptional accessory protein -
GC56T3_RS19105 239103..239216 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
GC56T3_RS01275 239306..239755 + 450 WP_013144047.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T24772 WP_003253417.1 NC_014206:236303-236653 [Geobacillus sp. C56-T3]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T24772 NC_014206:236303-236653 [Geobacillus sp. C56-T3]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGACCTTTCCCCGGTTGTTGGCTCGGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGTTTTAGCCCGACGGTGATTGTCGCGGCGATTACGGCGCAAATCCAAAAAG
CGAAGCTGCCGACGCATGTCGAGATTGACGCGAAACGCTACGGGTTTGAACGCGATTCGGTCATTTTGCTTGAGCAAATT
CGCACGATCGACAAGCAACGGCTGACCGATAAAATCACTCATTTGGACGATGAAATGATGGATAAAGTCGATGAGGCGCT
GCAAATTAGCTTAGGACTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10669.17 Da        Isoelectric Point: 7.2027

>AT24772 WP_013144044.1 NC_014206:236017-236298 [Geobacillus sp. C56-T3]
VSESGATTEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT24772 NC_014206:236017-236298 [Geobacillus sp. C56-T3]
GTGTCGGAATCTGGCGCAACAACGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGTGCTCGTAAA
GCAGGAAAACGGCAACCGCAATGAACTCATTTATCAAGCGACGAAAATGTACATTCGCGAGCGGAAGAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCGAAAATCAATTTATCTATCGCTTCTGAAGCGTTTCATGCTGAATAC
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8C733

References