Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1366294..1366882 Replicon chromosome
Accession NZ_CP098511
Organism Aquimarina sp. ERC-38

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NBT05_RS05855 Protein ID WP_265772556.1
Coordinates 1366294..1366596 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NBT05_RS05860 Protein ID WP_265772557.1
Coordinates 1366598..1366882 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBT05_RS05830 (NBT05_05825) 1361565..1362599 - 1035 WP_265772551.1 ferrochelatase -
NBT05_RS05835 (NBT05_05830) 1362817..1362987 + 171 WP_265772552.1 hypothetical protein -
NBT05_RS05840 (NBT05_05835) 1362995..1363885 - 891 WP_265772553.1 AraC family transcriptional regulator -
NBT05_RS05845 (NBT05_05840) 1364070..1365320 + 1251 WP_265772554.1 glutamyl-tRNA reductase -
NBT05_RS05850 (NBT05_05845) 1365322..1366236 + 915 WP_265772555.1 hydroxymethylbilane synthase -
NBT05_RS05855 (NBT05_05850) 1366294..1366596 + 303 WP_265772556.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBT05_RS05860 (NBT05_05855) 1366598..1366882 + 285 WP_265772557.1 putative addiction module antidote protein Antitoxin
NBT05_RS05865 (NBT05_05860) 1367039..1367641 + 603 WP_265772558.1 uroporphyrinogen-III synthase -
NBT05_RS05870 (NBT05_05865) 1367664..1368689 + 1026 WP_265772560.1 uroporphyrinogen decarboxylase -
NBT05_RS05875 (NBT05_05870) 1368759..1369181 + 423 WP_265772561.1 hypothetical protein -
NBT05_RS05880 (NBT05_05875) 1369218..1370123 + 906 WP_265772562.1 oxygen-dependent coproporphyrinogen oxidase -
NBT05_RS05885 (NBT05_05880) 1370375..1370995 + 621 WP_265772563.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 12053.14 Da        Isoelectric Point: 10.5404

>T247718 WP_265772556.1 NZ_CP098511:1366294-1366596 [Aquimarina sp. ERC-38]
MFFIEKTKEFNKWFRKLKDSKAKTKILYRIQRLENDEHFGDCKPVGDGIKEIRINFAKEYRIYFKEKNGRIIILLIGGDK
STQQKDIKKAKEIWNKLNNL

Download         Length: 303 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10070.62 Da        Isoelectric Point: 4.5535

>AT247718 WP_265772557.1 NZ_CP098511:1366598-1366882 [Aquimarina sp. ERC-38]
METSKFDIADYLDSKEMIVEYLNTVLEEGNDADMVVAIGHVAKAIGMSKIAEETGLSRPSLYKALSDGAKPQFATIVKVL
KAIGGQIQINPLSA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References