Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 51877..52454 Replicon plasmid pLM58-55
Accession NZ_CP098508
Organism Listeria monocytogenes strain L58-55

Toxin (Protein)


Gene name mazF Uniprot ID H1G8D6
Locus tag BES38_RS15205 Protein ID WP_003728465.1
Coordinates 52113..52454 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1G8D5
Locus tag BES38_RS15200 Protein ID WP_003728464.1
Coordinates 51877..52119 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BES38_RS15175 (BES38_15170) 49403..49651 - 249 WP_009911232.1 hypothetical protein -
BES38_RS15180 (BES38_15175) 50050..50427 - 378 WP_003769263.1 DUF3850 domain-containing protein -
BES38_RS15185 (BES38_15180) 50446..51108 - 663 WP_003731676.1 DUF2786 domain-containing protein -
BES38_RS15190 (BES38_15185) 51108..51434 - 327 WP_031641563.1 hypothetical protein -
BES38_RS15195 (BES38_15190) 51580..51816 + 237 WP_003769265.1 hypothetical protein -
BES38_RS15200 (BES38_15195) 51877..52119 + 243 WP_003728464.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BES38_RS15205 (BES38_15200) 52113..52454 + 342 WP_003728465.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BES38_RS15210 (BES38_15205) 52480..52623 - 144 WP_157105793.1 hypothetical protein -
BES38_RS15215 (BES38_15210) 52677..53648 - 972 WP_031641941.1 hypothetical protein -
BES38_RS15220 (BES38_15215) 53652..53906 - 255 WP_031641560.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ClpL - 1..61167 61167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12827.74 Da        Isoelectric Point: 9.2830

>T247717 WP_003728465.1 NZ_CP098508:52113-52454 [Listeria monocytogenes]
MVKQGDIIKINLNPKQGHEQQGYRPYICLSHHLVSDYANIAIFAPISNTPRTYPLYVPLTGTTTTGKVLLDQLVTIDYNA
RKHQYVETVSDPLLTKLLDTVKVIFQKNERSTN

Download         Length: 342 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9207.48 Da        Isoelectric Point: 4.3867

>AT247717 WP_003728464.1 NZ_CP098508:51877-52119 [Listeria monocytogenes]
MTTVSVKKWGNSKAVRLPNNLLNALDIKENDDLKVEVINNQMILTKTAIDLRIEDLFANYQGEPFQTELQTFEPIGDEKW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H1G8D6

Antitoxin

Source ID Structure
AlphaFold DB H1G8D5

References