Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 723788..724443 Replicon chromosome
Accession NZ_CP098505
Organism Neisseria gonorrhoeae strain 10536

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDL72_RS03890 Protein ID WP_003691083.1
Coordinates 724024..724443 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDL72_RS03885 Protein ID WP_003688410.1
Coordinates 723788..724024 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL72_RS03855 (NDL72_03820) 718922..719209 + 288 WP_003688407.1 hypothetical protein -
NDL72_RS03860 (NDL72_03825) 719281..720447 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
NDL72_RS03865 (NDL72_03830) 720458..721348 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NDL72_RS03870 (NDL72_03835) 721731..722117 - 387 Protein_752 transposase -
NDL72_RS03875 (NDL72_03840) 722467..722757 + 291 WP_041420764.1 helix-turn-helix domain-containing protein -
NDL72_RS03880 (NDL72_03845) 722762..723340 + 579 WP_003688041.1 IS3 family transposase -
NDL72_RS03885 (NDL72_03850) 723788..724024 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDL72_RS03890 (NDL72_03855) 724024..724443 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDL72_RS03895 (NDL72_03860) 724592..726046 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDL72_RS03900 (NDL72_03865) 726043..726744 - 702 WP_003688414.1 lactate utilization protein C -
NDL72_RS03905 (NDL72_03870) 726741..727520 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDL72_RS03910 (NDL72_03875) 727668..729209 + 1542 WP_003697015.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247715 WP_003691083.1 NZ_CP098505:724024-724443 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247715 WP_003688410.1 NZ_CP098505:723788-724024 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References