247713

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 185205..185860 Replicon chromosome
Accession NZ_CP098503
Organism Neisseria gonorrhoeae strain 10268

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NDL73_RS01025 Protein ID WP_229931500.1
Coordinates 185441..185860 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDL73_RS01020 Protein ID WP_003688410.1
Coordinates 185205..185441 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDL73_RS00990 (NDL73_04910) 180340..180627 + 288 WP_003688407.1 hypothetical protein -
NDL73_RS00995 (NDL73_04905) 180699..181865 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDL73_RS01000 (NDL73_04900) 181876..182766 + 891 WP_229931474.1 succinate--CoA ligase subunit alpha -
NDL73_RS01005 (NDL73_04895) 183149..183535 - 387 Protein_197 transposase -
NDL73_RS01010 (NDL73_04890) 183774..184175 + 402 WP_020996834.1 helix-turn-helix domain-containing protein -
NDL73_RS01015 (NDL73_04885) 184180..184758 + 579 WP_003697246.1 IS3 family transposase -
NDL73_RS01020 (NDL73_04880) 185205..185441 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDL73_RS01025 (NDL73_04875) 185441..185860 + 420 WP_229931500.1 type II toxin-antitoxin system toxin FitB Toxin
NDL73_RS01030 (NDL73_04870) 186009..187463 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDL73_RS01035 (NDL73_04865) 187460..188161 - 702 WP_003688414.1 lactate utilization protein C -
NDL73_RS01040 (NDL73_04860) 188158..188937 - 780 WP_003688416.1 (Fe-S)-binding protein -
NDL73_RS01045 (NDL73_04855) 189085..190626 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 183083..183556 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15336.67 Da        Isoelectric Point: 5.5742

>T247713 WP_229931500.1 NZ_CP098503:185441-185860 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGWILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247713 WP_003688410.1 NZ_CP098503:185205-185441 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References