Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 471788..472411 Replicon chromosome
Accession NZ_CP098500
Organism Serratia symbiotica strain Pl-LLN

Toxin (Protein)


Gene name Hha Uniprot ID E9CPA8
Locus tag M5J15_RS02500 Protein ID WP_006709525.1
Coordinates 471788..471991 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag M5J15_RS02505 Protein ID WP_252748422.1
Coordinates 472043..472411 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5J15_RS02480 (M5J15_02475) 468064..469836 + 1773 WP_252748420.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
M5J15_RS02485 (M5J15_02480) 470077..470415 + 339 WP_252748421.1 P-II family nitrogen regulator -
M5J15_RS02490 (M5J15_02485) 470661..470903 - 243 Protein_492 methylated-DNA--[protein]-cysteine S-methyltransferase -
M5J15_RS02500 (M5J15_02495) 471788..471991 - 204 WP_006709525.1 HHA domain-containing protein Toxin
M5J15_RS02505 (M5J15_02500) 472043..472411 - 369 WP_252748422.1 Hha toxicity modulator TomB Antitoxin
M5J15_RS02510 (M5J15_02505) 472927..474006 - 1080 Protein_495 ISAs1 family transposase -
M5J15_RS02515 (M5J15_02510) 474273..474446 - 174 WP_252748423.1 hypothetical protein -
M5J15_RS02520 (M5J15_02515) 474432..475145 + 714 WP_252748424.1 ABC transporter ATP-binding protein -
M5J15_RS02525 (M5J15_02520) 475142..475999 + 858 WP_252748425.1 metal ABC transporter permease -
M5J15_RS02530 (M5J15_02525) 476027..476908 + 882 WP_252748426.1 metal ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8090.38 Da        Isoelectric Point: 7.9816

>T247710 WP_006709525.1 NZ_CP098500:c471991-471788 [Serratia symbiotica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSNDELELFYSAADHRLAELTMNKLYDKIPTAVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14191.98 Da        Isoelectric Point: 4.3135

>AT247710 WP_252748422.1 NZ_CP098500:c472411-472043 [Serratia symbiotica]
MDEYSSKRHDIAQLKFLCENLYDEGIATLDDSCHGWVNDPTSFVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DNAYMLFSGYGINDSDLRRWQKTTAKLFRMFSGEGICTTMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068R9C7

Antitoxin

Source ID Structure

References