Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 124562..125172 Replicon chromosome
Accession NZ_CP098500
Organism Serratia symbiotica strain Pl-LLN

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M5J15_RS00700 Protein ID WP_252748197.1
Coordinates 124562..124741 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5J15_RS00705 Protein ID WP_252748198.1
Coordinates 124762..125172 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5J15_RS00685 (M5J15_00685) 120117..120713 - 597 WP_252748194.1 deoxyribose-phosphate aldolase -
M5J15_RS00690 (M5J15_00690) 121411..122181 - 771 WP_252748195.1 TatD family hydrolase -
M5J15_RS00695 (M5J15_00695) 122765..124354 - 1590 WP_252748196.1 peptide chain release factor 3 -
M5J15_RS00700 (M5J15_00700) 124562..124741 + 180 WP_252748197.1 type II toxin-antitoxin system HicA family toxin Toxin
M5J15_RS00705 (M5J15_00705) 124762..125172 + 411 WP_252748198.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5J15_RS00710 (M5J15_00710) 125292..125855 - 564 WP_284700490.1 Ig-like domain-containing protein -
M5J15_RS00715 (M5J15_00715) 126303..126747 - 445 Protein_143 ribosomal protein S18-alanine N-acetyltransferase -
M5J15_RS00720 (M5J15_00720) 126692..127129 - 438 WP_252748200.1 DNA polymerase III subunit psi -
M5J15_RS00725 (M5J15_00725) 127276..128322 + 1047 WP_252748201.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
M5J15_RS00735 (M5J15_00735) 129251..129298 + 48 Protein_146 hypothetical protein -
M5J15_RS00740 (M5J15_00740) 129743..130031 - 289 Protein_147 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6672.91 Da        Isoelectric Point: 10.9132

>T247708 WP_252748197.1 NZ_CP098500:124562-124741 [Serratia symbiotica]
MGSRNAIVMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQEGL

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14814.89 Da        Isoelectric Point: 4.3299

>AT247708 WP_252748198.1 NZ_CP098500:124762-125172 [Serratia symbiotica]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESVREAIDAHIELLMEDGEAVPEATSVENWLADPDYAGVVWALVD
VDVIRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRLAADKVIGRVKI

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References