Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1354942..1355858 Replicon chromosome
Accession NZ_CP098491
Organism Bacillus subtilis strain NB205

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag NDK36_RS07205 Protein ID WP_003244695.1
Coordinates 1355112..1355858 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NDK36_RS07200 Protein ID WP_003232646.1
Coordinates 1354942..1355112 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDK36_RS07165 (NDK36_07165) 1351801..1352130 + 330 WP_014479562.1 XkdW family protein -
NDK36_RS07170 (NDK36_07170) 1352127..1352291 + 165 WP_014479563.1 XkdX family protein -
NDK36_RS07175 (NDK36_07175) 1352338..1353177 + 840 WP_014479564.1 phage-like element PBSX protein XepA -
NDK36_RS07180 (NDK36_07180) 1353230..1353499 + 270 WP_014479565.1 hemolysin XhlA family protein -
NDK36_RS07185 (NDK36_07185) 1353512..1353775 + 264 WP_014479566.1 phage holin -
NDK36_RS07190 (NDK36_07190) 1353788..1354681 + 894 WP_014479567.1 N-acetylmuramoyl-L-alanine amidase -
NDK36_RS07195 (NDK36_07195) 1354719..1354856 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NDK36_RS07200 (NDK36_07200) 1354942..1355112 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NDK36_RS07205 (NDK36_07205) 1355112..1355858 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NDK36_RS07210 (NDK36_07210) 1355968..1356969 - 1002 WP_014479569.1 inorganic phosphate transporter -
NDK36_RS07215 (NDK36_07215) 1356982..1357599 - 618 WP_003218470.1 DUF47 domain-containing protein -
NDK36_RS07220 (NDK36_07220) 1357875..1359191 - 1317 WP_014479570.1 serine/threonine exchanger -
NDK36_RS07225 (NDK36_07225) 1359580..1360530 + 951 WP_014479571.1 ring-cleaving dioxygenase -
NDK36_RS07230 (NDK36_07230) 1360639..1360734 + 96 Protein_1365 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T247704 WP_003244695.1 NZ_CP098491:c1355858-1355112 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT247704 WP_003232646.1 NZ_CP098491:c1355112-1354942 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References