Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3860575..3861356 Replicon chromosome
Accession NZ_CP098486
Organism Enterobacter hormaechei subsp. hormaechei strain ECC33

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A431SHU0
Locus tag NDJ97_RS18550 Protein ID WP_022649378.1
Coordinates 3860575..3861066 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3S0FY21
Locus tag NDJ97_RS18555 Protein ID WP_022649379.1
Coordinates 3861063..3861356 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDJ97_RS18535 (NDJ97_18530) 3855855..3856307 - 453 WP_022649375.1 hypothetical protein -
NDJ97_RS18540 (NDJ97_18535) 3856822..3858732 + 1911 WP_022649376.1 hypothetical protein -
NDJ97_RS18545 (NDJ97_18540) 3858729..3860423 + 1695 WP_022649377.1 hypothetical protein -
NDJ97_RS18550 (NDJ97_18545) 3860575..3861066 - 492 WP_022649378.1 GNAT family N-acetyltransferase Toxin
NDJ97_RS18555 (NDJ97_18550) 3861063..3861356 - 294 WP_022649379.1 DUF1778 domain-containing protein Antitoxin
NDJ97_RS18560 (NDJ97_18555) 3861458..3863251 - 1794 WP_022649380.1 hybrid sensor histidine kinase/response regulator -
NDJ97_RS18565 (NDJ97_18560) 3863248..3863880 - 633 WP_022649381.1 response regulator transcription factor -
NDJ97_RS18570 (NDJ97_18565) 3864056..3864370 + 315 WP_003862457.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3855855..3864370 8515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17469.36 Da        Isoelectric Point: 8.1405

>T247701 WP_022649378.1 NZ_CP098486:c3861066-3860575 [Enterobacter hormaechei subsp. hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTTNTVPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10959.58 Da        Isoelectric Point: 8.6351

>AT247701 WP_022649379.1 NZ_CP098486:c3861356-3861063 [Enterobacter hormaechei subsp. hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SHU0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S0FY21

References