Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2276556..2277295 Replicon chromosome
Accession NZ_CP098486
Organism Enterobacter hormaechei subsp. hormaechei strain ECC33

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NDJ97_RS11025 Protein ID WP_022648141.1
Coordinates 2276556..2277041 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NDJ97_RS11030 Protein ID WP_003857131.1
Coordinates 2277029..2277295 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDJ97_RS11000 (NDJ97_11000) 2272712..2273734 + 1023 WP_022648135.1 alpha/beta hydrolase -
NDJ97_RS11005 (NDJ97_11005) 2273830..2274594 + 765 WP_022648136.1 SDR family oxidoreductase -
NDJ97_RS11010 (NDJ97_11010) 2275261..2275524 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NDJ97_RS11015 (NDJ97_11015) 2275499..2275828 - 330 WP_022648139.1 hypothetical protein -
NDJ97_RS11020 (NDJ97_11020) 2275961..2276530 + 570 WP_022648140.1 hypothetical protein -
NDJ97_RS11025 (NDJ97_11025) 2276556..2277041 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NDJ97_RS11030 (NDJ97_11030) 2277029..2277295 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NDJ97_RS11035 (NDJ97_11035) 2277359..2278288 - 930 WP_022648142.1 LysR family transcriptional regulator -
NDJ97_RS11040 (NDJ97_11040) 2278418..2279806 + 1389 WP_022648143.1 MFS transporter -
NDJ97_RS11045 (NDJ97_11045) 2279785..2280342 - 558 WP_022648144.1 OmpH family outer membrane protein -
NDJ97_RS11050 (NDJ97_11050) 2280463..2281599 - 1137 WP_022648145.1 type 1 fimbrial protein -
NDJ97_RS11055 (NDJ97_11055) 2281623..2282201 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2253689..2280342 26653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T247694 WP_022648141.1 NZ_CP098486:c2277041-2276556 [Enterobacter hormaechei subsp. hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT247694 WP_003857131.1 NZ_CP098486:c2277295-2277029 [Enterobacter hormaechei subsp. hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References