Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 319587..320235 Replicon chromosome
Accession NZ_CP098483
Organism Stenotrophomonas maltophilia strain 142

Toxin (Protein)


Gene name PumA Uniprot ID B2FJ07
Locus tag NDK23_RS01425 Protein ID WP_012478870.1
Coordinates 319587..319874 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NDK23_RS01430 Protein ID WP_012478871.1
Coordinates 319933..320235 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDK23_RS01395 (NDK23_01395) 314847..315815 + 969 WP_012478821.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
NDK23_RS01400 (NDK23_01400) 315812..316543 + 732 WP_005407698.1 type III pantothenate kinase -
NDK23_RS01405 (NDK23_01405) 316553..317401 + 849 WP_012478822.1 SPOR domain-containing protein -
NDK23_RS01415 (NDK23_01415) 317602..318726 - 1125 WP_012478868.1 hypothetical protein -
NDK23_RS01420 (NDK23_01420) 318754..319353 - 600 WP_012478869.1 hypothetical protein -
NDK23_RS01425 (NDK23_01425) 319587..319874 + 288 WP_012478870.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDK23_RS01430 (NDK23_01430) 319933..320235 + 303 WP_012478871.1 putative addiction module antidote protein Antitoxin
NDK23_RS01435 (NDK23_01435) 320293..320616 - 324 WP_012478872.1 hypothetical protein -
NDK23_RS01440 (NDK23_01440) 320696..321103 - 408 WP_044569408.1 hypothetical protein -
NDK23_RS01445 (NDK23_01445) 321697..322467 + 771 WP_012478874.1 DUF3011 domain-containing protein -
NDK23_RS01450 (NDK23_01450) 322506..323471 + 966 WP_224481934.1 ankyrin repeat domain-containing protein -
NDK23_RS01455 (NDK23_01455) 323576..324496 + 921 WP_005407709.1 arginase -
NDK23_RS01460 (NDK23_01460) 324657..324794 + 138 WP_005407710.1 entericidin A/B family lipoprotein -
NDK23_RS01465 (NDK23_01465) 325002..325223 + 222 WP_004153772.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10802.42 Da        Isoelectric Point: 10.8940

>T247691 WP_012478870.1 NZ_CP098483:319587-319874 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSS
QQRDIEKAREIARAL

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10738.32 Da        Isoelectric Point: 8.0343

>AT247691 WP_012478871.1 NZ_CP098483:319933-320235 [Stenotrophomonas maltophilia]
MATKKKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854E218

Antitoxin

Source ID Structure

References