Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 131514..133097 Replicon chromosome
Accession NZ_CP098483
Organism Stenotrophomonas maltophilia strain 142

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NDK23_RS00560 Protein ID WP_076738896.1
Coordinates 131514..132836 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NDK23_RS00565 Protein ID WP_005407534.1
Coordinates 132840..133097 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDK23_RS00545 (NDK23_00545) 126909..128543 - 1635 WP_005407530.1 TldD/PmbA family protein -
NDK23_RS00550 (NDK23_00550) 128574..130205 - 1632 WP_049395460.1 TldD/PmbA family protein -
NDK23_RS00555 (NDK23_00555) 130899..131513 + 615 WP_049397989.1 DUF938 domain-containing protein -
NDK23_RS00560 (NDK23_00560) 131514..132836 - 1323 WP_076738896.1 type II toxin-antitoxin system HipA family toxin Toxin
NDK23_RS00565 (NDK23_00565) 132840..133097 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
NDK23_RS00570 (NDK23_00570) 133259..136945 - 3687 WP_044569327.1 indolepyruvate ferredoxin oxidoreductase family protein -
NDK23_RS00575 (NDK23_00575) 137117..137752 + 636 WP_076738897.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49046.94 Da        Isoelectric Point: 7.0868

>T247690 WP_076738896.1 NZ_CP098483:c132836-131514 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPARPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCTPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT247690 WP_005407534.1 NZ_CP098483:c133097-132840 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References