Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1404553..1405406 Replicon chromosome
Accession NC_014169
Organism Bifidobacterium longum subsp. longum JDM301

Toxin (Protein)


Gene name relE Uniprot ID D6ZUU6
Locus tag BLJ_RS06060 Protein ID WP_013140895.1
Coordinates 1404553..1405044 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6XX41
Locus tag BLJ_RS06065 Protein ID WP_008783109.1
Coordinates 1405044..1405406 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BLJ_RS06045 (BLJ_1196) 1400291..1401193 - 903 WP_013140890.1 Bax inhibitor-1/YccA family protein -
BLJ_RS10860 (BLJ_1197) 1401477..1401617 + 141 Protein_1182 DNA-binding response regulator -
BLJ_RS06050 (BLJ_1199) 1401658..1402299 + 642 WP_013140893.1 GNAT family N-acetyltransferase -
BLJ_RS06055 (BLJ_1200) 1402388..1404493 + 2106 WP_013140894.1 DUF262 domain-containing protein -
BLJ_RS06060 (BLJ_1201) 1404553..1405044 - 492 WP_013140895.1 PIN domain-containing protein Toxin
BLJ_RS06065 (BLJ_1202) 1405044..1405406 - 363 WP_008783109.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BLJ_RS06070 (BLJ_1203) 1405552..1408251 - 2700 WP_013140896.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18314.88 Da        Isoelectric Point: 4.5590

>T24769 WP_013140895.1 NC_014169:c1405044-1404553 [Bifidobacterium longum subsp. longum JDM301]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T24769 NC_014169:c1405044-1404553 [Bifidobacterium longum subsp. longum JDM301]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGTGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCACTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAACTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13974.03 Da        Isoelectric Point: 5.0733

>AT24769 WP_008783109.1 NC_014169:c1405406-1405044 [Bifidobacterium longum subsp. longum JDM301]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Download         Length: 363 bp

>AT24769 NC_014169:c1405406-1405044 [Bifidobacterium longum subsp. longum JDM301]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTAAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A564VMG8

Antitoxin

Source ID Structure
AlphaFold DB V6XX41

References