Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1404553..1405406 Replicon chromosome
Accession NC_014169
Organism Bifidobacterium longum subsp. longum JDM301

Toxin (Protein)


Gene name relE Uniprot ID D6ZUU6
Locus tag BLJ_RS06060 Protein ID WP_013140895.1
Coordinates 1404553..1405044 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6XX41
Locus tag BLJ_RS06065 Protein ID WP_008783109.1
Coordinates 1405044..1405406 (-) Length 121 a.a.

Genomic Context

BLJ_RS10860BLJ_RS06050BLJ_RS06055BLJ_RS06045BLJ_RS06060BLJ_RS06065BLJ_RS06070
Location: 1401477..1401617 (141 bp)
Type: Others
Protein ID: Protein_1182
Location: 1401658..1402299 (642 bp)
Type: Others
Protein ID: WP_013140893.1
Location: 1402388..1404493 (2106 bp)
Type: Others
Protein ID: WP_013140894.1
Location: 1400291..1401193 (903 bp)
Type: Others
Protein ID: WP_013140890.1
Location: 1404553..1405044 (492 bp)
Type: Toxin
Protein ID: WP_013140895.1
Location: 1405044..1405406 (363 bp)
Type: Antitoxin
Protein ID: WP_008783109.1
Location: 1405552..1408251 (2700 bp)
Type: Others
Protein ID: WP_013140896.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BLJ_RS06045 (BLJ_1196)1400291..1401193-903WP_013140890.1Bax inhibitor-1/YccA family protein-
BLJ_RS10860 (BLJ_1197)1401477..1401617+141Protein_1182DNA-binding response regulator-
BLJ_RS06050 (BLJ_1199)1401658..1402299+642WP_013140893.1GNAT family N-acetyltransferase-
BLJ_RS06055 (BLJ_1200)1402388..1404493+2106WP_013140894.1DUF262 domain-containing protein-
BLJ_RS06060 (BLJ_1201)1404553..1405044-492WP_013140895.1PIN domain-containing proteinToxin
BLJ_RS06065 (BLJ_1202)1405044..1405406-363WP_008783109.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
BLJ_RS06070 (BLJ_1203)1405552..1408251-2700WP_013140896.1aconitate hydratase AcnA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18314.88 Da        Isoelectric Point: 4.5590

>T24769 WP_013140895.1 NC_014169:c1405044-1404553 [Bifidobacterium longum subsp. longum JDM301]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T24769 NC_014169:c1405044-1404553 [Bifidobacterium longum subsp. longum JDM301]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGTGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCACTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAACTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13974.03 Da        Isoelectric Point: 5.0733

>AT24769 WP_008783109.1 NC_014169:c1405406-1405044 [Bifidobacterium longum subsp. longum JDM301]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Download         Length: 363 bp

>AT24769 NC_014169:c1405406-1405044 [Bifidobacterium longum subsp. longum JDM301]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTAAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A564VMG8

Antitoxin

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Source
ID
Structure
AlphaFold DBV6XX41

References