247685

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1708..2171 Replicon plasmid pJD1
Accession NZ_CP098475
Organism Neisseria gonorrhoeae strain 10239

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NC847_RS11780 Protein ID WP_003690225.1
Coordinates 1708..1986 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NC847_RS11785 Protein ID WP_003690223.1
Coordinates 1986..2171 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC847_RS11765 (NC847_11685) 75..704 + 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
NC847_RS11770 (NC847_11690) 788..1429 + 642 WP_146711211.1 MbeB family mobilization protein -
NC847_RS11775 (NC847_11695) 1476..1730 + 255 WP_003690227.1 Cryptic plasmid protein A -
NC847_RS11780 (NC847_11700) 1708..1986 - 279 WP_003690225.1 endoribonuclease VapD Toxin
NC847_RS11785 (NC847_11705) 1986..2171 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
NC847_RS11790 (NC847_11710) 2174..2419 - 246 WP_003690221.1 hypothetical protein -
NC847_RS11795 (NC847_11715) 2416..2658 - 243 WP_003690220.1 HTH domain-containing protein -
NC847_RS11800 (NC847_11720) 2662..3531 - 870 WP_260237151.1 replication initiation protein -
NC847_RS11805 (NC847_11725) 3614..3838 - 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247685 WP_003690225.1 NZ_CP098475:c1986-1708 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT247685 WP_003690223.1 NZ_CP098475:c2171-1986 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References