Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1008..1471 Replicon plasmid pJD1
Accession NZ_CP098473
Organism Neisseria gonorrhoeae strain 10612

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NC855_RS11720 Protein ID WP_003690225.1
Coordinates 1008..1286 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NC855_RS11725 Protein ID WP_003690223.1
Coordinates 1286..1471 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC855_RS11710 (NC855_11665) 88..729 + 642 WP_003690229.1 MbeB family mobilization protein -
NC855_RS11715 (NC855_11670) 776..1030 + 255 WP_003690227.1 Cryptic plasmid protein A -
NC855_RS11720 (NC855_11625) 1008..1286 - 279 WP_003690225.1 endoribonuclease VapD Toxin
NC855_RS11725 (NC855_11630) 1286..1471 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
NC855_RS11730 (NC855_11635) 1474..1719 - 246 WP_003690221.1 hypothetical protein -
NC855_RS11735 (NC855_11640) 1716..1958 - 243 WP_003690220.1 HTH domain-containing protein -
NC855_RS11740 (NC855_11645) 1962..2831 - 870 WP_003690219.1 replication initiation protein -
NC855_RS11745 (NC855_11650) 2914..3138 - 225 WP_025455920.1 hypothetical protein -
NC855_RS11750 (NC855_11655) 3217..3597 + 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247682 WP_003690225.1 NZ_CP098473:c1286-1008 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT247682 WP_003690223.1 NZ_CP098473:c1471-1286 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References