Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1036..1499 Replicon plasmid pJD1
Accession NZ_CP098471
Organism Neisseria gonorrhoeae strain 10792

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NC854_RS11730 Protein ID WP_003690225.1
Coordinates 1036..1314 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NC854_RS11735 Protein ID WP_003690223.1
Coordinates 1314..1499 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC854_RS11720 (NC854_11585) 116..757 + 642 WP_003690229.1 MbeB family mobilization protein -
NC854_RS11725 (NC854_11625) 804..1058 + 255 WP_003690227.1 Cryptic plasmid protein A -
NC854_RS11730 (NC854_11620) 1036..1314 - 279 WP_003690225.1 endoribonuclease VapD Toxin
NC854_RS11735 (NC854_11615) 1314..1499 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
NC854_RS11740 (NC854_11610) 1502..1747 - 246 WP_003690221.1 hypothetical protein -
NC854_RS11745 (NC854_11605) 1744..1986 - 243 WP_003690220.1 HTH domain-containing protein -
NC854_RS11750 (NC854_11600) 1990..2859 - 870 WP_003690219.1 replication initiation protein -
NC854_RS11755 (NC854_11595) 3245..3625 + 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247679 WP_003690225.1 NZ_CP098471:c1314-1036 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT247679 WP_003690223.1 NZ_CP098471:c1499-1314 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References