Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 495..958 Replicon plasmid pJD1
Accession NZ_CP098469
Organism Neisseria gonorrhoeae strain 10328

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag NC853_RS11660 Protein ID WP_003690225.1
Coordinates 495..773 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag NC853_RS11665 Protein ID WP_003690223.1
Coordinates 773..958 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC853_RS11655 (NC853_11570) 263..517 + 255 WP_003690227.1 Cryptic plasmid protein A -
NC853_RS11660 (NC853_11565) 495..773 - 279 WP_003690225.1 endoribonuclease VapD Toxin
NC853_RS11665 (NC853_11560) 773..958 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
NC853_RS11670 (NC853_11555) 961..1206 - 246 WP_003690221.1 hypothetical protein -
NC853_RS11675 (NC853_11550) 1203..1445 - 243 WP_003690220.1 HTH domain-containing protein -
NC853_RS11680 (NC853_11545) 1449..2318 - 870 WP_003690219.1 replication initiation protein -
NC853_RS11685 (NC853_11585) 2704..3084 + 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
NC853_RS11690 (NC853_11580) 3069..3698 + 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T247676 WP_003690225.1 NZ_CP098469:c773-495 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT247676 WP_003690223.1 NZ_CP098469:c958-773 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References