Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 951938..952593 Replicon chromosome
Accession NZ_CP098468
Organism Neisseria gonorrhoeae strain 10328

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NC853_RS04920 Protein ID WP_003691083.1
Coordinates 951938..952357 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NC853_RS04925 Protein ID WP_003688410.1
Coordinates 952357..952593 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC853_RS04900 (NC853_04845) 947172..948713 - 1542 WP_003691084.1 MDR family MFS transporter -
NC853_RS04905 (NC853_04850) 948861..949640 + 780 WP_003688416.1 (Fe-S)-binding protein -
NC853_RS04910 (NC853_04855) 949637..950338 + 702 WP_003688414.1 lactate utilization protein C -
NC853_RS04915 (NC853_04860) 950335..951789 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NC853_RS04920 (NC853_04865) 951938..952357 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NC853_RS04925 (NC853_04870) 952357..952593 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NC853_RS04930 (NC853_04875) 953040..953618 - 579 WP_003697246.1 IS3 family transposase -
NC853_RS04935 (NC853_04880) 953623..953913 - 291 WP_047917062.1 helix-turn-helix domain-containing protein -
NC853_RS04940 (NC853_04885) 954263..954649 + 387 Protein_970 transposase -
NC853_RS04945 (NC853_04890) 955032..955922 - 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
NC853_RS04950 (NC853_04895) 955933..957099 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NC853_RS04955 (NC853_04900) 957171..957458 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 954242..954715 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247674 WP_003691083.1 NZ_CP098468:c952357-951938 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247674 WP_003688410.1 NZ_CP098468:c952593-952357 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References