Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 950624..951279 Replicon chromosome
Accession NZ_CP098464
Organism Neisseria gonorrhoeae strain 10269

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NC851_RS04915 Protein ID WP_229931500.1
Coordinates 950624..951043 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NC851_RS04920 Protein ID WP_003688410.1
Coordinates 951043..951279 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC851_RS04895 (NC851_04850) 945858..947399 - 1542 WP_003691084.1 MDR family MFS transporter -
NC851_RS04900 (NC851_04855) 947547..948326 + 780 WP_003688416.1 (Fe-S)-binding protein -
NC851_RS04905 (NC851_04860) 948323..949024 + 702 WP_003688414.1 lactate utilization protein C -
NC851_RS04910 (NC851_04865) 949021..950475 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NC851_RS04915 (NC851_04870) 950624..951043 - 420 WP_229931500.1 type II toxin-antitoxin system toxin FitB Toxin
NC851_RS04920 (NC851_04875) 951043..951279 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NC851_RS04925 (NC851_04880) 951726..952304 - 579 WP_003697246.1 IS3 family transposase -
NC851_RS04930 (NC851_04885) 952309..952710 - 402 WP_020996834.1 helix-turn-helix domain-containing protein -
NC851_RS04935 (NC851_04890) 952949..953335 + 387 Protein_969 IS110 family transposase -
NC851_RS04940 (NC851_04895) 953718..954608 - 891 WP_229931474.1 succinate--CoA ligase subunit alpha -
NC851_RS04945 (NC851_04900) 954619..955785 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NC851_RS04950 (NC851_04905) 955857..956144 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15336.67 Da        Isoelectric Point: 5.5742

>T247669 WP_229931500.1 NZ_CP098464:c951043-950624 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGWILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247669 WP_003688410.1 NZ_CP098464:c951279-951043 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References