Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 661248..661903 Replicon chromosome
Accession NZ_CP098462
Organism Neisseria gonorrhoeae strain 9460

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NC849_RS03510 Protein ID WP_003691083.1
Coordinates 661484..661903 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NC849_RS03505 Protein ID WP_003688410.1
Coordinates 661248..661484 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC849_RS03475 (NC849_03460) 656382..656669 + 288 WP_003688407.1 hypothetical protein -
NC849_RS03480 (NC849_03465) 656741..657907 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
NC849_RS03485 (NC849_03470) 657918..658808 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
NC849_RS03490 (NC849_03475) 659191..659577 - 387 Protein_682 transposase -
NC849_RS03495 (NC849_03480) 659816..660217 + 402 WP_020997339.1 helix-turn-helix domain-containing protein -
NC849_RS03500 (NC849_03485) 660222..660800 + 579 WP_003688041.1 IS3 family transposase -
NC849_RS03505 (NC849_03490) 661248..661484 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NC849_RS03510 (NC849_03495) 661484..661903 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NC849_RS03515 (NC849_03500) 662052..663506 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NC849_RS03520 (NC849_03505) 663503..664204 - 702 WP_003688414.1 lactate utilization protein C -
NC849_RS03525 (NC849_03510) 664201..664980 - 780 WP_003688416.1 (Fe-S)-binding protein -
NC849_RS03530 (NC849_03515) 665128..666669 + 1542 WP_003701286.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247667 WP_003691083.1 NZ_CP098462:661484-661903 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247667 WP_003688410.1 NZ_CP098462:661248-661484 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References