Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 952124..952779 Replicon chromosome
Accession NZ_CP098460
Organism Neisseria gonorrhoeae strain 10814

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NC848_RS04920 Protein ID WP_003691083.1
Coordinates 952124..952543 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NC848_RS04925 Protein ID WP_003688410.1
Coordinates 952543..952779 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC848_RS04900 (NC848_04855) 947358..948899 - 1542 WP_003691084.1 MDR family MFS transporter -
NC848_RS04905 (NC848_04860) 949047..949826 + 780 WP_003688416.1 (Fe-S)-binding protein -
NC848_RS04910 (NC848_04865) 949823..950524 + 702 WP_003688414.1 lactate utilization protein C -
NC848_RS04915 (NC848_04870) 950521..951975 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NC848_RS04920 (NC848_04875) 952124..952543 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NC848_RS04925 (NC848_04880) 952543..952779 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NC848_RS04930 (NC848_04885) 953226..953804 - 579 WP_003697246.1 IS3 family transposase -
NC848_RS04935 (NC848_04890) 953809..954099 - 291 WP_047917062.1 helix-turn-helix domain-containing protein -
NC848_RS04940 (NC848_04895) 954449..954835 + 387 Protein_970 transposase -
NC848_RS04945 (NC848_04900) 955218..956108 - 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
NC848_RS04950 (NC848_04905) 956119..957285 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NC848_RS04955 (NC848_04910) 957357..957644 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 954428..954901 473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247665 WP_003691083.1 NZ_CP098460:c952543-952124 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247665 WP_003688410.1 NZ_CP098460:c952779-952543 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References