Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 657447..658102 Replicon chromosome
Accession NZ_CP098458
Organism Neisseria gonorrhoeae strain 10588

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NC846_RS03515 Protein ID WP_003691083.1
Coordinates 657683..658102 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NC846_RS03510 Protein ID WP_003688410.1
Coordinates 657447..657683 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NC846_RS03480 (NC846_03460) 652582..652869 + 288 WP_003688407.1 hypothetical protein -
NC846_RS03485 (NC846_03465) 652941..654107 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NC846_RS03490 (NC846_03470) 654118..655008 + 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
NC846_RS03495 (NC846_03475) 655391..655777 - 387 Protein_682 transposase -
NC846_RS03500 (NC846_03480) 656127..656417 + 291 WP_047917062.1 helix-turn-helix domain-containing protein -
NC846_RS03505 (NC846_03485) 656422..657000 + 579 WP_003697246.1 IS3 family transposase -
NC846_RS03510 (NC846_03490) 657447..657683 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NC846_RS03515 (NC846_03495) 657683..658102 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NC846_RS03520 (NC846_03500) 658251..659705 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NC846_RS03525 (NC846_03505) 659702..660403 - 702 WP_003688414.1 lactate utilization protein C -
NC846_RS03530 (NC846_03510) 660400..661179 - 780 WP_003688416.1 (Fe-S)-binding protein -
NC846_RS03535 (NC846_03515) 661327..662868 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T247663 WP_003691083.1 NZ_CP098458:657683-658102 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT247663 WP_003688410.1 NZ_CP098458:657447-657683 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References