Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 985000..985555 Replicon chromosome
Accession NC_014169
Organism Bifidobacterium longum subsp. longum JDM301

Toxin (Protein)


Gene name mazF Uniprot ID D6ZTS1
Locus tag BLJ_RS04095 Protein ID WP_013140587.1
Coordinates 985000..985323 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D6ZTS2
Locus tag BLJ_RS04100 Protein ID WP_013140588.1
Coordinates 985310..985555 (-) Length 82 a.a.

Genomic Context

BLJ_RS04085BLJ_RS10660BLJ_RS04105BLJ_RS10655BLJ_RS04080BLJ_RS04095BLJ_RS04100BLJ_RS04110BLJ_RS04115
Location: 983487..984062 (576 bp)
Type: Others
Protein ID: Protein_799
Location: 984169..984783 (615 bp)
Type: Others
Protein ID: WP_003829107.1
Location: 985726..986982 (1257 bp)
Type: Others
Protein ID: WP_003829116.1
Location: 981077..982341 (1265 bp)
Type: Others
Protein ID: Protein_797
Location: 982884..983249 (366 bp)
Type: Others
Protein ID: WP_013140585.1
Location: 985000..985323 (324 bp)
Type: Toxin
Protein ID: WP_013140587.1
Location: 985310..985555 (246 bp)
Type: Antitoxin
Protein ID: WP_013140588.1
Location: 987405..988676 (1272 bp)
Type: Others
Protein ID: WP_013140589.1
Location: 988833..989495 (663 bp)
Type: Others
Protein ID: WP_038426133.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BLJ_RS10655 (BLJ_0807)981077..982341-1265Protein_797Fic family protein-
BLJ_RS04080 (BLJ_0808)982884..983249-366WP_013140585.1YccF domain-containing protein-
BLJ_RS04085 (BLJ_0809)983487..984062+576Protein_799class I SAM-dependent methyltransferase-
BLJ_RS10660 (BLJ_0810)984169..984783+615WP_003829107.1cupin domain-containing protein-
BLJ_RS04095 (BLJ_0811)985000..985323-324WP_013140587.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BLJ_RS04100 (BLJ_0812)985310..985555-246WP_013140588.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
BLJ_RS04105 (BLJ_0813)985726..986982+1257WP_003829116.1HipA domain-containing protein-
BLJ_RS04110 (BLJ_0814)987405..988676-1272WP_013140589.1MFS transporter-
BLJ_RS04115 (BLJ_0816)988833..989495-663WP_038426133.1TetR/AcrR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11801.59 Da        Isoelectric Point: 6.2932

>T24766 WP_013140587.1 NC_014169:c985323-985000 [Bifidobacterium longum subsp. longum JDM301]
MKRGEIRTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVADDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

>T24766 NC_014169:c985323-985000 [Bifidobacterium longum subsp. longum JDM301]
ATGAAACGAGGTGAGATTCGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCGGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGCT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGCTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9293.39 Da        Isoelectric Point: 4.7719

>AT24766 WP_013140588.1 NC_014169:c985555-985310 [Bifidobacterium longum subsp. longum JDM301]
MSIQIATRVSDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp

>AT24766 NC_014169:c985555-985310 [Bifidobacterium longum subsp. longum JDM301]
ATGAGCATACAGATTGCCACGCGAGTTAGTGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCAGGCAGCTGGGTACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4KDK5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A087BFX1

References