Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4165480..4167051 Replicon chromosome
Accession NZ_CP098450
Organism Proteus mirabilis strain FZP3115

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NBG99_RS19700 Protein ID WP_063073818.1
Coordinates 4165480..4166793 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBG99_RS19705 Protein ID WP_049203075.1
Coordinates 4166794..4167051 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBG99_RS19680 (NBG99_19680) 4160649..4161452 + 804 WP_063073815.1 energy transducer TonB -
NBG99_RS19685 (NBG99_19685) 4161506..4163362 - 1857 WP_226694093.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
NBG99_RS19690 (NBG99_19690) 4163499..4164428 - 930 WP_004246518.1 metallophosphoesterase -
NBG99_RS19695 (NBG99_19695) 4164613..4165077 - 465 WP_063073817.1 DUF1097 domain-containing protein -
NBG99_RS19700 (NBG99_19700) 4165480..4166793 - 1314 WP_063073818.1 type II toxin-antitoxin system HipA family toxin Toxin
NBG99_RS19705 (NBG99_19705) 4166794..4167051 - 258 WP_049203075.1 helix-turn-helix domain-containing protein Antitoxin
NBG99_RS19710 (NBG99_19710) 4167200..4168564 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
NBG99_RS19715 (NBG99_19715) 4168702..4170342 - 1641 WP_004246512.1 membrane protein insertase YidC -
NBG99_RS19720 (NBG99_19720) 4170345..4170605 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
NBG99_RS19725 (NBG99_19725) 4170569..4170928 - 360 WP_004246510.1 ribonuclease P protein component -
NBG99_RS19730 (NBG99_19730) 4170946..4171089 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49674.86 Da        Isoelectric Point: 6.7643

>T247659 WP_063073818.1 NZ_CP098450:c4166793-4165480 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLVAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKKYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT247659 WP_049203075.1 NZ_CP098450:c4167051-4166794 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References