Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3785349..3786048 Replicon chromosome
Accession NZ_CP098450
Organism Proteus mirabilis strain FZP3115

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NBG99_RS17915 Protein ID WP_017628658.1
Coordinates 3785349..3785735 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag NBG99_RS17920 Protein ID WP_004246828.1
Coordinates 3785728..3786048 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBG99_RS17900 (NBG99_17900) 3781368..3781949 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
NBG99_RS17905 (NBG99_17905) 3782200..3783105 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
NBG99_RS17910 (NBG99_17910) 3783115..3785187 + 2073 WP_017628659.1 glycine--tRNA ligase subunit beta -
NBG99_RS17915 (NBG99_17915) 3785349..3785735 + 387 WP_017628658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBG99_RS17920 (NBG99_17920) 3785728..3786048 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
NBG99_RS17925 (NBG99_17925) 3786097..3786531 - 435 WP_004246827.1 hypothetical protein -
NBG99_RS17930 (NBG99_17930) 3786524..3787408 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
NBG99_RS17935 (NBG99_17935) 3787623..3788909 - 1287 WP_063073863.1 DUF3748 domain-containing protein -
NBG99_RS17940 (NBG99_17940) 3789046..3789663 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
NBG99_RS17945 (NBG99_17945) 3789964..3790587 + 624 WP_004246821.1 guanylate kinase -
NBG99_RS17950 (NBG99_17950) 3790642..3790917 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14322.65 Da        Isoelectric Point: 10.0826

>T247657 WP_017628658.1 NZ_CP098450:3785349-3785735 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT247657 WP_004246828.1 NZ_CP098450:3785728-3786048 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References