247648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3338201..3339222 Replicon chromosome
Accession NZ_CP098447
Organism Proteus mirabilis strain FZP2936

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag NBG97_RS15975 Protein ID WP_004249488.1
Coordinates 3338653..3339222 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag NBG97_RS15970 Protein ID WP_004245528.1
Coordinates 3338201..3338653 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBG97_RS15950 (NBG97_15950) 3333987..3334517 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
NBG97_RS15955 (NBG97_15955) 3334834..3335799 + 966 WP_049195511.1 thiamine ABC transporter substrate binding subunit -
NBG97_RS15960 (NBG97_15960) 3335799..3337379 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
NBG97_RS15965 (NBG97_15965) 3337372..3338073 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
NBG97_RS15970 (NBG97_15970) 3338201..3338653 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
NBG97_RS15975 (NBG97_15975) 3338653..3339222 + 570 WP_004249488.1 PIN domain-containing protein Toxin
NBG97_RS15980 (NBG97_15980) 3339338..3341692 + 2355 WP_017628571.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21600.10 Da        Isoelectric Point: 7.3470

>T247648 WP_004249488.1 NZ_CP098447:3338653-3339222 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT247648 WP_004245528.1 NZ_CP098447:3338201-3338653 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References