Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1846515..1847314 Replicon chromosome
Accession NZ_CP098447
Organism Proteus mirabilis strain FZP2936

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A8E3RD10
Locus tag NBG97_RS08910 Protein ID WP_004247966.1
Coordinates 1846790..1847314 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID B4EVS2
Locus tag NBG97_RS08905 Protein ID WP_004247964.1
Coordinates 1846515..1846793 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBG97_RS08880 (NBG97_08880) 1841865..1842947 + 1083 WP_004242680.1 peptide chain release factor 1 -
NBG97_RS08885 (NBG97_08885) 1842947..1843795 + 849 WP_004247962.1 peptide chain release factor N(5)-glutamine methyltransferase -
NBG97_RS08890 (NBG97_08890) 1843773..1844588 + 816 WP_004242688.1 invasion regulator SirB1 -
NBG97_RS08895 (NBG97_08895) 1844646..1845500 + 855 WP_004242689.1 3-deoxy-8-phosphooctulonate synthase -
NBG97_RS08900 (NBG97_08900) 1845508..1846437 + 930 WP_017628160.1 TIGR01212 family radical SAM protein -
NBG97_RS08905 (NBG97_08905) 1846515..1846793 + 279 WP_004247964.1 DUF1778 domain-containing protein Antitoxin
NBG97_RS08910 (NBG97_08910) 1846790..1847314 + 525 WP_004247966.1 hypothetical protein Toxin
NBG97_RS08915 (NBG97_08915) 1847395..1849095 - 1701 WP_017628159.1 C4-dicarboxylic acid transporter DauA -
NBG97_RS08925 (NBG97_08925) 1850059..1851000 + 942 WP_004242695.1 glyoxylate/hydroxypyruvate reductase GhrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19192.12 Da        Isoelectric Point: 9.3561

>T247647 WP_004247966.1 NZ_CP098447:1846790-1847314 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Download         Length: 525 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10252.82 Da        Isoelectric Point: 5.1369

>AT247647 WP_004247964.1 NZ_CP098447:1846515-1846793 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EVS2

References