Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1608854..1609499 | Replicon | chromosome |
| Accession | NZ_CP098447 | ||
| Organism | Proteus mirabilis strain FZP2936 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | B4ET86 |
| Locus tag | NBG97_RS07670 | Protein ID | WP_004247035.1 |
| Coordinates | 1609314..1609499 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | B4ET85 |
| Locus tag | NBG97_RS07665 | Protein ID | WP_004247034.1 |
| Coordinates | 1608854..1609267 (-) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBG97_RS07635 (NBG97_07635) | 1604407..1604565 | - | 159 | WP_004247025.1 | hypothetical protein | - |
| NBG97_RS07640 (NBG97_07640) | 1605017..1605193 | + | 177 | WP_004247793.1 | hypothetical protein | - |
| NBG97_RS07645 (NBG97_07645) | 1605364..1606110 | - | 747 | Protein_1473 | methyltransferase domain-containing protein | - |
| NBG97_RS07650 (NBG97_07650) | 1606960..1607538 | + | 579 | WP_017628400.1 | alpha/beta hydrolase | - |
| NBG97_RS07655 (NBG97_07655) | 1607651..1607893 | - | 243 | WP_230458803.1 | hypothetical protein | - |
| NBG97_RS07660 (NBG97_07660) | 1608258..1608758 | - | 501 | WP_004247032.1 | response regulator | - |
| NBG97_RS07665 (NBG97_07665) | 1608854..1609267 | - | 414 | WP_004247034.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| NBG97_RS07670 (NBG97_07670) | 1609314..1609499 | - | 186 | WP_004247035.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| NBG97_RS07675 (NBG97_07675) | 1609605..1610072 | + | 468 | WP_223293438.1 | DUF1073 domain-containing protein | - |
| NBG97_RS07680 (NBG97_07680) | 1610015..1610383 | + | 369 | WP_223293455.1 | DUF1073 domain-containing protein | - |
| NBG97_RS07685 (NBG97_07685) | 1610389..1610610 | + | 222 | Protein_1481 | hypothetical protein | - |
| NBG97_RS07690 (NBG97_07690) | 1610939..1611490 | - | 552 | WP_017628396.1 | PH domain-containing protein | - |
| NBG97_RS07695 (NBG97_07695) | 1611554..1611868 | - | 315 | WP_017628395.1 | hypothetical protein | - |
| NBG97_RS07705 (NBG97_07705) | 1612275..1614008 | - | 1734 | WP_017628394.1 | LPS biosynthesis-modulating metalloenzyme YejM | - |
| NBG97_RS07710 (NBG97_07710) | 1614032..1614259 | - | 228 | WP_004247042.1 | YejL family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1598979..1621481 | 22502 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 7049.30 Da Isoelectric Point: 10.9659
>T247646 WP_004247035.1 NZ_CP098447:c1609499-1609314 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN
Download Length: 186 bp
Antitoxin
Download Length: 138 a.a. Molecular weight: 15251.98 Da Isoelectric Point: 4.3830
>AT247646 WP_004247034.1 NZ_CP098447:c1609267-1608854 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
Download Length: 414 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|