Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4020657..4022228 Replicon chromosome
Accession NZ_CP098446
Organism Proteus mirabilis strain FZP2826

Toxin (Protein)


Gene name hipA Uniprot ID B4F0T8
Locus tag NBG95_RS18550 Protein ID WP_012368637.1
Coordinates 4020657..4021970 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag NBG95_RS18555 Protein ID WP_004249771.1
Coordinates 4021971..4022228 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBG95_RS18530 (NBG95_18530) 4015825..4016628 + 804 WP_104836842.1 energy transducer TonB -
NBG95_RS18535 (NBG95_18535) 4016682..4018643 - 1962 WP_172767808.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
NBG95_RS18540 (NBG95_18540) 4018675..4019604 - 930 WP_004246518.1 metallophosphoesterase -
NBG95_RS18545 (NBG95_18545) 4019789..4020253 - 465 WP_012368636.1 DUF1097 domain-containing protein -
NBG95_RS18550 (NBG95_18550) 4020657..4021970 - 1314 WP_012368637.1 type II toxin-antitoxin system HipA family toxin Toxin
NBG95_RS18555 (NBG95_18555) 4021971..4022228 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
NBG95_RS18560 (NBG95_18560) 4022377..4023741 - 1365 WP_012368638.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
NBG95_RS18565 (NBG95_18565) 4023879..4025519 - 1641 WP_004246512.1 membrane protein insertase YidC -
NBG95_RS18570 (NBG95_18570) 4025522..4025782 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
NBG95_RS18575 (NBG95_18575) 4025746..4026105 - 360 WP_004246510.1 ribonuclease P protein component -
NBG95_RS18580 (NBG95_18580) 4026123..4026266 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49670.78 Da        Isoelectric Point: 6.5023

>T247644 WP_012368637.1 NZ_CP098446:c4021970-4020657 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT247644 WP_004249771.1 NZ_CP098446:c4022228-4021971 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4F0T8

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References