Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3721993..3722692 Replicon chromosome
Accession NZ_CP098446
Organism Proteus mirabilis strain FZP2826

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag NBG95_RS17215 Protein ID WP_004249093.1
Coordinates 3721993..3722379 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag NBG95_RS17220 Protein ID WP_004246828.1
Coordinates 3722372..3722692 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBG95_RS17200 (NBG95_17200) 3718012..3718593 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
NBG95_RS17205 (NBG95_17205) 3718844..3719749 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
NBG95_RS17210 (NBG95_17210) 3719759..3721831 + 2073 WP_017628659.1 glycine--tRNA ligase subunit beta -
NBG95_RS17215 (NBG95_17215) 3721993..3722379 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBG95_RS17220 (NBG95_17220) 3722372..3722692 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
NBG95_RS17225 (NBG95_17225) 3722741..3723175 - 435 WP_004246827.1 hypothetical protein -
NBG95_RS17230 (NBG95_17230) 3723168..3724052 - 885 WP_004249091.1 endonuclease/exonuclease/phosphatase family protein -
NBG95_RS17235 (NBG95_17235) 3724267..3725553 - 1287 WP_087741020.1 DUF3748 domain-containing protein -
NBG95_RS17240 (NBG95_17240) 3725690..3726307 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
NBG95_RS17245 (NBG95_17245) 3726608..3727231 + 624 WP_004246821.1 guanylate kinase -
NBG95_RS17250 (NBG95_17250) 3727286..3727561 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T247643 WP_004249093.1 NZ_CP098446:3721993-3722379 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT247643 WP_004246828.1 NZ_CP098446:3722372-3722692 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References