Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 3359492..3361214 | Replicon | chromosome |
| Accession | NZ_CP098446 | ||
| Organism | Proteus mirabilis strain FZP2826 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A0U2S2I2 |
| Locus tag | NBG95_RS15610 | Protein ID | WP_064497040.1 |
| Coordinates | 3359492..3360430 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A934MVJ4 |
| Locus tag | NBG95_RS15615 | Protein ID | WP_000095577.1 |
| Coordinates | 3360423..3361214 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBG95_RS15590 (NBG95_15590) | 3355433..3355945 | - | 513 | WP_175215521.1 | S26 family signal peptidase | - |
| NBG95_RS15595 (NBG95_15595) | 3355929..3356276 | - | 348 | WP_064497038.1 | hypothetical protein | - |
| NBG95_RS15600 (NBG95_15600) | 3356269..3358668 | - | 2400 | WP_064497039.1 | type IV secretion system protein TraC | - |
| NBG95_RS15605 (NBG95_15605) | 3358668..3359360 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| NBG95_RS15610 (NBG95_15610) | 3359492..3360430 | - | 939 | WP_064497040.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NBG95_RS15615 (NBG95_15615) | 3360423..3361214 | - | 792 | WP_000095577.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| NBG95_RS15620 (NBG95_15620) | 3361435..3361821 | - | 387 | WP_032469918.1 | TraA family conjugative transfer protein | - |
| NBG95_RS15625 (NBG95_15625) | 3361818..3362390 | - | 573 | WP_024008834.1 | type IV conjugative transfer system lipoprotein TraV | - |
| NBG95_RS15630 (NBG95_15630) | 3362465..3363754 | - | 1290 | WP_064497041.1 | TraB/VirB10 family protein | - |
| NBG95_RS15635 (NBG95_15635) | 3363757..3364653 | - | 897 | WP_064497055.1 | type-F conjugative transfer system secretin TraK | - |
| NBG95_RS15640 (NBG95_15640) | 3364637..3365263 | - | 627 | WP_064497042.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| NBG95_RS15645 (NBG95_15645) | 3365260..3365541 | - | 282 | WP_000433891.1 | type IV conjugative transfer system protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(J) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / fosA3 / aph(3')-Ia / tet(C) / aph(3'')-Ib / aph(6)-Id | - | 3238750..3436289 | 197539 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35542.81 Da Isoelectric Point: 4.9912
>T247642 WP_064497040.1 NZ_CP098446:c3360430-3359492 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
Antitoxin
Download Length: 264 a.a. Molecular weight: 30109.49 Da Isoelectric Point: 9.5097
>AT247642 WP_000095577.1 NZ_CP098446:c3361214-3360423 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|