Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3177343..3178364 Replicon chromosome
Accession NZ_CP098446
Organism Proteus mirabilis strain FZP2826

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A8E4FRK4
Locus tag NBG95_RS14780 Protein ID WP_017827532.1
Coordinates 3177795..3178364 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag NBG95_RS14775 Protein ID WP_004245528.1
Coordinates 3177343..3177795 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBG95_RS14755 (NBG95_14755) 3173129..3173659 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
NBG95_RS14760 (NBG95_14760) 3173976..3174941 + 966 WP_049195511.1 thiamine ABC transporter substrate binding subunit -
NBG95_RS14765 (NBG95_14765) 3174941..3176521 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
NBG95_RS14770 (NBG95_14770) 3176514..3177215 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
NBG95_RS14775 (NBG95_14775) 3177343..3177795 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
NBG95_RS14780 (NBG95_14780) 3177795..3178364 + 570 WP_017827532.1 PIN domain-containing protein Toxin
NBG95_RS14785 (NBG95_14785) 3178480..3180834 + 2355 WP_036895567.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21601.08 Da        Isoelectric Point: 7.0180

>T247641 WP_017827532.1 NZ_CP098446:3177795-3178364 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT247641 WP_004245528.1 NZ_CP098446:3177343-3177795 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References