Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4176322..4176838 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag M9193_RS20185 Protein ID WP_000220578.1
Coordinates 4176322..4176606 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag M9193_RS20190 Protein ID WP_000212724.1
Coordinates 4176596..4176838 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS20170 (4171534) 4171534..4173186 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
M9193_RS20175 (4173595) 4173595..4175733 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
M9193_RS20180 (4175854) 4175854..4176318 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M9193_RS20185 (4176322) 4176322..4176606 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9193_RS20190 (4176596) 4176596..4176838 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M9193_RS20195 (4176916) 4176916..4178829 - 1914 WP_001212137.1 BglG family transcription antiterminator -
M9193_RS20200 (4178846) 4178846..4179586 - 741 WP_000779263.1 KDGP aldolase family protein -
M9193_RS20205 (4179583) 4179583..4180701 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
M9193_RS20210 (4180685) 4180685..4181818 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T247631 WP_000220578.1 NZ_CP098438:c4176606-4176322 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT247631 WP_000212724.1 NZ_CP098438:c4176838-4176596 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References