Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 4082061..4082637 | Replicon | chromosome |
Accession | NZ_CP098438 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6 |
Toxin (Protein)
Gene name | shpA | Uniprot ID | M7RG88 |
Locus tag | M9193_RS19785 | Protein ID | WP_001131963.1 |
Coordinates | 4082350..4082637 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | B5R9R5 |
Locus tag | M9193_RS19780 | Protein ID | WP_000063142.1 |
Coordinates | 4082061..4082363 (-) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M9193_RS19765 (4078571) | 4078571..4080721 | + | 2151 | WP_000379927.1 | pyruvate/proton symporter BtsT | - |
M9193_RS19770 (4080816) | 4080816..4081019 | + | 204 | WP_000460616.1 | YbdD/YjiX family protein | - |
M9193_RS19775 (4081030) | 4081030..4081986 | + | 957 | WP_000187839.1 | GTPase | - |
M9193_RS19780 (4082061) | 4082061..4082363 | - | 303 | WP_000063142.1 | BrnA antitoxin family protein | Antitoxin |
M9193_RS19785 (4082350) | 4082350..4082637 | - | 288 | WP_001131963.1 | BrnT family toxin | Toxin |
M9193_RS19790 (4082906) | 4082906..4083820 | - | 915 | WP_000290512.1 | restriction endonuclease | - |
M9193_RS19795 (4084018) | 4084018..4087527 | + | 3510 | WP_001043485.1 | type I restriction-modification system endonuclease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11294.80 Da Isoelectric Point: 9.5894
>T247630 WP_001131963.1 NZ_CP098438:c4082637-4082350 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG
Download Length: 288 bp
Antitoxin
Download Length: 101 a.a. Molecular weight: 11373.96 Da Isoelectric Point: 10.1293
>AT247630 WP_000063142.1 NZ_CP098438:c4082363-4082061 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK
Download Length: 303 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 7VD7 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 7VD7 | |
AlphaFold DB | A0A4D6PB01 |