Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3482100..3482720 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag M9193_RS17030 Protein ID WP_001280991.1
Coordinates 3482502..3482720 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag M9193_RS17025 Protein ID WP_000344807.1
Coordinates 3482100..3482474 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS17015 (3477239) 3477239..3478432 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M9193_RS17020 (3478455) 3478455..3481604 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
M9193_RS17025 (3482100) 3482100..3482474 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
M9193_RS17030 (3482502) 3482502..3482720 + 219 WP_001280991.1 HHA domain-containing protein Toxin
M9193_RS17035 (3482899) 3482899..3483450 + 552 WP_001278792.1 maltose O-acetyltransferase -
M9193_RS17040 (3483567) 3483567..3484037 + 471 WP_000136181.1 YlaC family protein -
M9193_RS17045 (3484093) 3484093..3484233 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
M9193_RS17050 (3484239) 3484239..3484499 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
M9193_RS17055 (3484724) 3484724..3486274 + 1551 WP_000213139.1 EAL domain-containing protein -
M9193_RS17065 (3486505) 3486505..3486894 + 390 WP_000961285.1 MGMT family protein -
M9193_RS17070 (3486927) 3486927..3487496 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T247627 WP_001280991.1 NZ_CP098438:3482502-3482720 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT247627 WP_000344807.1 NZ_CP098438:3482100-3482474 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References